Version 5.4
Mus musculus Gene: Sh2d3c
Summary
InnateDB Gene IDBG-161162.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sh2d3c
Gene Name SH2 domain containing 3C
Synonyms Chat; Nsp3; Shep1
Species Mus musculus
Ensembl Gene ENSMUSG00000059013
Encoded Proteins
IDBP-161164
SH2 domain containing 3C
IDBP-254287
SH2 domain containing 3C
IDBP-537805
SH2 domain containing 3C
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000095370:
This gene encodes an adaptor protein and member of a cytoplasmic protein family involved in cell migration. The encoded protein contains a putative Src homology 2 (SH2) domain and guanine nucleotide exchange factor-like domain which allows this signaling protein to form a complex with scaffolding protein Crk-associated substrate. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:32721055-32755512
Strand Forward strand
Band B
Transcripts
ENSMUST00000074248 ENSMUSP00000073866
ENSMUST00000113242 ENSMUSP00000108868
ENSMUST00000124133
ENSMUST00000141670
ENSMUST00000131101 ENSMUSP00000122613
ENSMUST00000139563
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 5 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
Biological Process
GO:0007165 signal transduction
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0043087 regulation of GTPase activity
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000095370
View Gene Order
ENSBTAG00000015375
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_11
TCR pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001252547 NM_013781 XM_006498096
OMIM
CCDS CCDS15928 CCDS57168
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca