InnateDB Protein
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IDBP-254295.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Crbn
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Protein Name
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cereblon
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Synonyms
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2610203G15Rik; 2900045O07Rik; AF229032; AW108261; piL;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000108865
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InnateDB Gene
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IDBG-174064 (Crbn)
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Protein Structure
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Function |
Component of some DCX (DDB1-CUL4-X-box) E3 protein ligase complex, a complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins and is required for limb outgrowth and expression of the fibroblast growth factor FGF8. In the complex, may act as a substrate receptor. Regulates the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1 (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Highly expressed in brain. {ECO:0000269PubMed:20131966}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
11 [view]
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Molecular Function |
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Biological Process |
GO:0006200
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ATP catabolic process
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GO:0006508
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proteolysis
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GO:0016567
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protein ubiquitination
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GO:0032463
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negative regulation of protein homooligomerization
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GO:0034766
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negative regulation of ion transmembrane transport
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GO:0043161
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proteasome-mediated ubiquitin-dependent protein catabolic process
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GO:0090073
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positive regulation of protein homodimerization activity
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Cellular Component |
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PDB ID |
MGI:1913277
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InterPro |
IPR003111
Peptidase S16, lon N-terminal
IPR015947
PUA-like domain
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PFAM |
PF02190
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PRINTS |
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PIRSF |
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SMART |
SM00464
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TIGRFAMs |
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Modification |
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SwissProt |
Q8C7D2
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PhosphoSite |
PhosphoSite-Q8C7D2
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
58799
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UniGene |
Mm.290085
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RefSeq |
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MGI ID |
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MGI Symbol |
Crbn
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OMIM |
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CCDS |
CCDS39583
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HPRD |
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IMGT |
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EMBL |
AF229032
AK050557
AK076144
AK077707
AK160219
BC046967
BC069905
BC086488
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GenPept |
AAF35895
AAH46967
AAH69905
AAH86488
BAC34322
BAC36214
BAC36970
BAE35697
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