Version 5.4
Mus musculus Protein: Irak1bp1
Summary
InnateDB Protein IDBP-254299.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Irak1bp1
Protein Name interleukin-1 receptor-associated kinase 1 binding protein 1
Synonyms 4921528N06Rik; Aabp3; AI851240; Aip70; Simpl;
Species Mus musculus
Ensembl Protein ENSMUSP00000108871
InnateDB Gene IDBG-188214 (Irak1bp1)
Protein Structure
UniProt Annotation
Function Component of the IRAK1-dependent TNFRSF1A signaling pathway that leads to NF-kappa-B activation and is required for cell survival. Acts by enhancing RELA transcriptional activity. {ECO:0000269PubMed:11096118, ECO:0000269PubMed:15485901}.
Subcellular Localization Cytoplasm {ECO:0000269PubMed:15485901}. Nucleus {ECO:0000269PubMed:15485901}.
Disease Associations
Tissue Specificity Expressed in testis, brain, kidney, liver and heart. {ECO:0000269PubMed:11096118}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007249 I-kappaB kinase/NF-kappaB signaling
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1929475
InterPro IPR007497 Protein of unknown function DUF541
PFAM PF04402
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9ESJ7
PhosphoSite PhosphoSite-Q9ESJ7
TrEMBL
UniProt Splice Variant
Entrez Gene 65099
UniGene Mm.41415
RefSeq NP_075362
MGI ID
MGI Symbol Irak1bp1
OMIM
CCDS CCDS23372
HPRD
IMGT
EMBL AF093135 AJ242722 AK009948 AK013036 AK020170 AK020448 AK045436 AK076594 BC061099
GenPept AAG16774 AAH61099 BAB26602 BAB32019 BAB32106 BAC25386 BAC32366 BAC36407 CAB92240

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca