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InnateDB Protein
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IDBP-254339.7
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Stxbp1
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Protein Name
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syntaxin binding protein 1
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Synonyms
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AI317162; AI326233; MMS10-G; Ms10g; Munc-18a; Munc18-1; N-sec1; nsec1; Rb-sec1; Sxtbp1; Unc18-1; Unc18h;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000108848
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InnateDB Gene
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IDBG-161623 (Stxbp1)
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Protein Structure
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| Function |
May participate in the regulation of synaptic vesicle docking and fusion, possibly through interaction with GTP-binding proteins. Essential for neurotransmission and binds syntaxin, a component of the synaptic vesicle fusion machinery probably in a 1:1 ratio. Can interact with syntaxins 1, 2, and 3 but not syntaxin 4. May play a role in determining the specificity of intracellular fusion reactions (By similarity). {ECO:0000250}.
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| Subcellular Localization |
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| Disease Associations |
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| Tissue Specificity |
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| Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
| Experimentally validated |
| Total |
17
[view]
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| Protein-Protein |
17
[view]
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| Protein-DNA |
0
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| Protein-RNA |
0
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| DNA-DNA |
0
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| RNA-RNA |
0
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| DNA-RNA |
0
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| Predicted by orthology |
| Total |
19 [view]
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Molecular Function |
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| Biological Process |
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| Cellular Component |
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| PDB ID |
MGI:107363
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| InterPro |
IPR001619
Sec1-like protein
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| PFAM |
PF00995
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| PRINTS |
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| PIRSF |
PIRSF005715
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| SMART |
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| TIGRFAMs |
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| Modification |
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| SwissProt |
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| PhosphoSite |
PhosphoSite-O08599
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| TrEMBL |
Z4YL99
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| UniProt Splice Variant |
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| Entrez Gene |
20910
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| UniGene |
Mm.449636
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| RefSeq |
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| MGI ID |
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| MGI Symbol |
Stxbp1
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| OMIM |
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| CCDS |
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| HPRD |
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| IMGT |
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| EMBL |
AL772271
AL845471
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| GenPept |
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Version 5.4