InnateDB Protein
|
IDBP-254349.6
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
Gene Symbol
|
Slc4a4
|
Protein Name
|
solute carrier family 4 (anion exchanger), member 4
|
Synonyms
|
AI835705; NBC; NBC1;
|
Species
|
Mus musculus
|
Ensembl Protein
|
ENSMUSP00000108842
|
InnateDB Gene
|
IDBG-177669 (Slc4a4)
|
Protein Structure
|
|
Function |
Electrogenic sodium/bicarbonate cotransporter with a Na(+):HCO3(-) stoichiometry varying from 1:2 to 1:3. May regulate bicarbonate influx/efflux at the basolateral membrane of cells and regulate intracellular pH.
|
Subcellular Localization |
Basolateral cell membrane {ECO:0000269PubMed:11171615}; Multi-pass membrane protein {ECO:0000269PubMed:11171615}.
|
Disease Associations |
|
Tissue Specificity |
Isoform 1 is specifically expressed in pancreatic ducts and acini. Also expressed in parotid acinar cells and in the colonic crypts. {ECO:0000269PubMed:11171615, ECO:0000269PubMed:12388213, ECO:0000269PubMed:12727194, ECO:0000269PubMed:9651366}.
|
Comments |
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
3
[view]
|
Protein-Protein |
3
[view]
|
Protein-DNA |
0
|
Protein-RNA |
0
|
DNA-DNA |
0
|
RNA-RNA |
0
|
DNA-RNA |
0
|
|
Predicted by orthology |
Total |
1 [view]
|
|
|
Molecular Function |
|
Biological Process |
|
Cellular Component |
|
PDB ID |
MGI:1927555
|
InterPro |
IPR013769
Band 3 cytoplasmic domain
IPR016152
Phosphotransferase/anion transporter
|
PFAM |
PF07565
|
PRINTS |
|
PIRSF |
|
SMART |
|
TIGRFAMs |
|
Modification |
|
SwissProt |
O88343
|
PhosphoSite |
PhosphoSite-O88343
|
TrEMBL |
|
UniProt Splice Variant |
|
Entrez Gene |
54403
|
UniGene |
Mm.41044
|
RefSeq |
|
MGI ID |
|
MGI Symbol |
Slc4a4
|
OMIM |
|
CCDS |
|
HPRD |
|
IMGT |
|
EMBL |
AF020195
AF141934
AK085387
AK140443
BC026592
|
GenPept |
AAC40160
AAD31036
AAH26592
BAC39437
BAE24389
|
|
|