Version 5.4
Mus musculus Protein: Btk
Summary
InnateDB Protein IDBP-254355.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Btk
Protein Name Bruton agammaglobulinemia tyrosine kinase
Synonyms AI528679; xid;
Species Mus musculus
Ensembl Protein ENSMUSP00000108839
InnateDB Gene IDBG-171427 (Btk)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 47 experimentally validated interaction(s) in this database.
They are also associated with 71 interaction(s) predicted by orthology.
Experimentally validated
Total 47 [view]
Protein-Protein 47 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 71 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
Biological Process
GO:0006468 protein phosphorylation
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0035556 intracellular signal transduction
GO:0045087 innate immune response (InnateDB)
GO:0048469 cell maturation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0031410 cytoplasmic vesicle
Protein Structure and Domains
PDB ID MGI:88216
InterPro IPR000719 Protein kinase domain
IPR000980 SH2 domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR001452 SH3 domain
IPR001562 Zinc finger, Btk motif
IPR001849 Pleckstrin homology domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR011511 Variant SH3 domain
IPR020635 Tyrosine-protein kinase, catalytic domain
PFAM PF00069
PF00017
PF14633
PF07714
PF00018
PF14604
PF00779
PF00169
PF07653
PRINTS PR00401
PR00109
PR00452
PR00402
PIRSF
SMART SM00252
SM00326
SM00107
SM00233
SM00220
SM00219
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL A2BDW0
UniProt Splice Variant
Entrez Gene 12229
UniGene Mm.4475
RefSeq
MGI ID
MGI Symbol Btk
OMIM
CCDS
HPRD
IMGT
EMBL AL672064 BX004852
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca