InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Lrsam1

Summary

InnateDB Protein

IDBP-254374.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Lrsam1

Protein Name

leucine rich repeat and sterile alpha motif containing 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000108825

InnateDB Gene

IDBG-161846 (Lrsam1)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase that mediates monoubiquitination of TSG101 at multiple sites, leading to inactivate the ability of TSG101 to sort endocytic (EGF receptors) cargos. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Note=Displays a punctuate distribution and localizes to a submembranal ring. {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed. {ECO:0000269PubMed:15256501}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 34 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	34 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity

Biological Process

GO:0000209	protein polyubiquitination
GO:0015031	protein transport
GO:0030163	protein catabolic process
GO:0045806	negative regulation of endocytosis
GO:0046755	non-lytic virus budding
GO:0051865	protein autoubiquitination
GO:0070086	ubiquitin-dependent endocytosis

Cellular Component

GO:0005737	cytoplasm
GO:0016020	membrane

Protein Structure and Domains

PDB ID

MGI:2684789

InterPro

IPR001611 Leucine-rich repeat
IPR001660 Sterile alpha motif domain
IPR001841 Zinc finger, RING-type
IPR003591 Leucine-rich repeat, typical subtype
IPR011510 Sterile alpha motif, type 2
IPR013761 Sterile alpha motif/pointed domain
IPR021129 Sterile alpha motif, type 1

PFAM