Version 5.4
Mus musculus Protein: Atg16l1
Summary
InnateDB Protein IDBP-254408.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Atg16l1
Protein Name autophagy-related 16-like 1 (yeast)
Synonyms 1500009K01Rik; Apg16l; Atg16l; WDR30;
Species Mus musculus
Ensembl Protein ENSMUSP00000108811
InnateDB Gene IDBG-178701 (Atg16l1)
Protein Structure
UniProt Annotation
Function Plays an essential role in autophagy: interacts with ATG12-ATG5 to mediate the conjugation of phosphatidylethanolamine (PE) to LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C), to produce a membrane-bound activated form of LC3 named LC3-II. Thereby, controls the elongation of the nascent autophagosomal membrane. {ECO:0000269PubMed:12665549, ECO:0000269PubMed:24553140}.
Subcellular Localization Cytoplasm. Preautophagosomal structure membrane; Peripheral membrane protein. Note=Localized to preautophagosomal structure (PAS) where it is involved in the membrane targeting of ATG5. Localizes also to discrete punctae along the ciliary axoneme.
Disease Associations
Tissue Specificity Widely expressed. In the liver, isoform 2 is highly expressed and isoform 1 is weakly expressed. Isoform 3 is expressed in the brain. {ECO:0000269PubMed:12665549}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 32 interaction(s) predicted by orthology.
Experimentally validated
Total 27 [view]
Protein-Protein 27 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 32 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0000045 autophagic vacuole assembly
GO:0015031 protein transport
GO:0039689 negative stranded viral RNA replication
Cellular Component
GO:0000421 autophagic vacuole membrane
GO:0005776 autophagic vacuole
GO:0005930 axoneme
GO:0034045 pre-autophagosomal structure membrane
Protein Structure and Domains
PDB ID MGI:1924290
InterPro IPR001680 WD40 repeat
IPR013923 Autophagy-related protein 16
IPR017986 WD40-repeat-containing domain
IPR020472 G-protein beta WD-40 repeat
PFAM PF00400
PF08614
PRINTS PR00320
PIRSF
SMART SM00320
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8C0J2
PhosphoSite PhosphoSite-Q8C0J2
TrEMBL Q3TDQ5
UniProt Splice Variant
Entrez Gene 77040
UniGene Mm.410937
RefSeq NP_001192321
MGI ID
MGI Symbol Atg16l1
OMIM
CCDS CCDS56638
HPRD
IMGT
EMBL AB087879 AB087880 AB087881 AC102630 AC159967 AK005181 AK030983 AK131120 AK155358 AK170073 BC049122 CH466520
GenPept AAH49122 BAB23866 BAC27201 BAC55090 BAC55091 BAC55092 BAD21370 BAE33214 BAE41546 EDL40148

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca