InnateDB Protein
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IDBP-254499.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ugt1a6a
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Protein Name
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UDP glucuronosyltransferase 1 family, polypeptide A6A
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000108760
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InnateDB Gene
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IDBG-179163 (Ugt1a6a)
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Protein Structure
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Function |
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Conjugates small planar phenolic molecules such as 4-nitrophenol, 1-naphthol, and 4-methylumbelliferone. The bulky phenol 4-hydroxybiphenyl, androgens and estrogens are not substrates. 2-hydroxybiphenyl is an excellent substrate.
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Subcellular Localization |
Microsome. Endoplasmic reticulum membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
Expressed in liver, kidney and at very low levels in colon. {ECO:0000269PubMed:14672974}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
1
[view]
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Protein-Protein |
0
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
Accession |
GO Term |
GO:0015020
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glucuronosyltransferase activity
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GO:0016758
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transferase activity, transferring hexosyl groups
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GO:0030246
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carbohydrate binding
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:3032636
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InterPro |
IPR002213
UDP-glucuronosyl/UDP-glucosyltransferase
IPR007235
Glycosyl transferase, family 28, C-terminal
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PFAM |
PF00201
PF04101
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q64435
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PhosphoSite |
PhosphoSite-Q64435
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TrEMBL |
D3YZE6
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UniProt Splice Variant |
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Entrez Gene |
94284
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UniGene |
Mm.467021
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RefSeq |
XP_006544546
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MGI ID |
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MGI Symbol |
Ugt1a7c
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OMIM |
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CCDS |
CCDS48314
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HPRD |
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IMGT |
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EMBL |
AC087780
AC087801
AY227197
D87867
U09930
U16818
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GenPept |
AAA51871
AAA65979
AAP48596
BAA13483
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