Version 5.4
| Mus musculus Gene: Ugt1a6a | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-179163.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | Ugt1a6a | ||||||||||||||||||
| Gene Name | UDP glucuronosyltransferase 1 family, polypeptide A6A | ||||||||||||||||||
| Synonyms | |||||||||||||||||||
| Species | Mus musculus | ||||||||||||||||||
| Ensembl Gene | ENSMUSG00000054545 | ||||||||||||||||||
| Encoded Proteins |
UDP glucuronosyltransferase 1 family, polypeptide A6A
UDP glucuronosyltransferase 1 family, polypeptide A6A
UDP glucuronosyltransferase 1 family, polypeptide A6A
UDP glucuronosyltransferase 1 family, polypeptide A6A
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000167165:
This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene is active on phenolic and planar compounds. Alternative splicing in the unique 5' end of this gene results in two transcript variants. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 1:88134809-88218997 | ||||||||||||||||||
| Strand | Forward strand | ||||||||||||||||||
| Band | D | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Homo sapiens
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Gene ID
Gene Order
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Phase II conjugation pathway
Metabolism pathway
Glucuronidation pathway
Biological oxidations pathway
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| KEGG |
Retinol metabolism pathway
Ascorbate and aldarate metabolism pathway
Starch and sucrose metabolism pathway
Pentose and glucuronate interconversions pathway
Porphyrin and chlorophyll metabolism pathway
Metabolism of xenobiotics by cytochrome P450 pathway
Steroid hormone biosynthesis pathway
Drug metabolism pathway
Drug metabolism pathway
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| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Glucuronidation pathway
Phase II conjugation pathway
Metabolism pathway
Biological oxidations pathway
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| KEGG |
Retinol metabolism pathway
Pentose and glucuronate interconversions pathway
Starch and sucrose metabolism pathway
Steroid hormone biosynthesis pathway
Ascorbate and aldarate metabolism pathway
Metabolism of xenobiotics by cytochrome P450 pathway
Porphyrin and chlorophyll metabolism pathway
Drug metabolism pathway
Drug metabolism pathway
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| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | Q64435 | ||||||||||||||||||
| TrEMBL | D3YZE6 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 94284 | ||||||||||||||||||
| UniGene | Mm.300095 Mm.412459 Mm.467021 | ||||||||||||||||||
| RefSeq | XM_006544484 XM_006544485 NM_145079 NM_201642 | ||||||||||||||||||
| OMIM | |||||||||||||||||||
| CCDS | CCDS48314 CCDS15139 | ||||||||||||||||||
| HPRD | |||||||||||||||||||
| IMGT | |||||||||||||||||||
| MGI ID | MGI:3032636 | ||||||||||||||||||
| MGI Symbol | Ugt1a7c | ||||||||||||||||||
| EMBL | AC087780 AC087801 AY227197 D87867 U09930 U16818 | ||||||||||||||||||
| GenPept | AAA51871 AAA65979 AAP48596 BAA13483 | ||||||||||||||||||
| RNA Seq Atlas | 102641635 394432 94284 | ||||||||||||||||||