InnateDB Protein
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IDBP-254537.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Mapkap1
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Protein Name
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mitogen-activated protein kinase associated protein 1
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000108749
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InnateDB Gene
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IDBG-162945 (Mapkap1)
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Protein Structure
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Function |
Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Isoform 1 is involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex. {ECO:0000269PubMed:16962653}.
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Subcellular Localization |
Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Nucleus {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
Uniquitously expresseed, with highest levels in testis, kidney and liver. Present in renal tubule cells (at protein level). {ECO:0000269PubMed:17054722}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 40 interaction(s) predicted by orthology.
Experimentally validated |
Total |
13
[view]
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Protein-Protein |
13
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
40 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:2444554
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InterPro |
IPR008828
Stress-activated map kinase interacting 1
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PFAM |
PF05422
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8BKH7
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PhosphoSite |
PhosphoSite-Q8BKH7
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
227743
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UniGene |
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RefSeq |
XP_006498041
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MGI ID |
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MGI Symbol |
Mapkap1
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AK027932
AK052045
AK132263
AL808102
AL845262
BC027377
BC031579
BC043296
BC090644
BC096618
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GenPept |
AAH27377
AAH31579
AAH43296
AAH90644
AAH96618
BAC25671
BAC34838
BAE21066
CAM15450
CAM15451
CAM15454
CAM17090
CAM17091
CAM17094
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