InnateDB Protein
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IDBP-254573.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ngfrap1
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Protein Name
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nerve growth factor receptor (TNFRSF16) associated protein 1
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Synonyms
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AL033356; Bex3; DXWsu67e; Gcap27; Nade;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000108738
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InnateDB Gene
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IDBG-173089 (Ngfrap1)
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Protein Structure
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Function |
May be a signaling adapter molecule involved in p75NTR- mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death. {ECO:0000269PubMed:10764727}.
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Subcellular Localization |
Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm and the nucleus. Associates with replicating mitochondria.
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Disease Associations |
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Tissue Specificity |
Widely expressed. {ECO:0000269PubMed:12935912, ECO:0000269PubMed:15563833}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated |
Total |
6
[view]
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Protein-Protein |
6
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
13 [view]
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Molecular Function |
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Biological Process |
GO:0008625
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extrinsic apoptotic signaling pathway via death domain receptors
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Cellular Component |
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PDB ID |
MGI:1338016
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InterPro |
IPR007623
Brain-expressed X-linked protein
IPR021156
Transcription elongation factor A-like/Brain expressed X-linked-like
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PFAM |
PF04538
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PRINTS |
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PIRSF |
PIRSF008633
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9WTZ9
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
12070
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UniGene |
Mm.413418
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RefSeq |
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MGI ID |
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MGI Symbol |
Ngfrap1
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OMIM |
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CCDS |
CCDS30419
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HPRD |
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IMGT |
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EMBL |
AF097440
AF187066
AK003294
AK004531
AK010500
AL671493
BC027815
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GenPept |
AAD24431
AAF75131
AAH27815
BAB22697
BAB23350
BAB26986
CAM45862
CAM45863
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