Version 5.4
Mus musculus Protein: Ngfrap1
Summary
InnateDB Protein IDBP-254575.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ngfrap1
Protein Name nerve growth factor receptor (TNFRSF16) associated protein 1
Synonyms AL033356; Bex3; DXWsu67e; Gcap27; Nade;
Species Mus musculus
Ensembl Protein ENSMUSP00000108737
InnateDB Gene IDBG-173089 (Ngfrap1)
Protein Structure
UniProt Annotation
Function May be a signaling adapter molecule involved in p75NTR- mediated apoptosis induced by NGF. Plays a role in zinc-triggered neuronal death. {ECO:0000269PubMed:10764727}.
Subcellular Localization Nucleus. Cytoplasm. Note=Shuttles between the cytoplasm and the nucleus. Associates with replicating mitochondria.
Disease Associations
Tissue Specificity Widely expressed. {ECO:0000269PubMed:12935912, ECO:0000269PubMed:15563833}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005123 death receptor binding
GO:0046872 metal ion binding
Biological Process
GO:0008625 extrinsic apoptotic signaling pathway via death domain receptors
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
Protein Structure and Domains
PDB ID MGI:1338016
InterPro IPR021156 Transcription elongation factor A-like/Brain expressed X-linked-like
PFAM PF04538
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9WTZ9
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 12070
UniGene Mm.413418
RefSeq NP_001103704
MGI ID
MGI Symbol Ngfrap1
OMIM
CCDS CCDS53194
HPRD
IMGT
EMBL AF097440 AF187066 AK003294 AK004531 AK010500 AL671493 BC027815
GenPept AAD24431 AAF75131 AAH27815 BAB22697 BAB23350 BAB26986 CAM45862 CAM45863

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca