InnateDB Protein
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IDBP-254626.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Plp1
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Protein Name
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proteolipid protein (myelin) 1
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Synonyms
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DM20; jimpy; jp; msd; Plp; rsh;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000108708
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InnateDB Gene
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IDBG-173392 (Plp1)
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Protein Structure
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Function |
This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.
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Subcellular Localization |
Cell membrane {ECO:0000269PubMed:17634366}; Multi-pass membrane protein {ECO:0000269PubMed:17634366}. Myelin membrane {ECO:0000269PubMed:17634366}. Note=Colocalizes with SIRT2 in internodal regions, at paranodal axoglial junction and Schmidt-Lanterman incisures of myelin sheat.
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Disease Associations |
Note=Defects in Plp1 are the cause of the dysmyelinating diseases Jimpy and Rumpshaker (rsh).
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated |
Total |
9
[view]
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Protein-Protein |
9
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
4 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:97623
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InterPro |
IPR001614
Myelin proteolipid protein PLP
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PFAM |
PF01275
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PRINTS |
PR00214
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PIRSF |
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SMART |
SM00002
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TIGRFAMs |
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Modification |
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SwissProt |
P60202
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PhosphoSite |
PhosphoSite-P60202
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
18823
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UniGene |
Mm.474648
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RefSeq |
NP_001277490
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MGI ID |
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MGI Symbol |
Plp1
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OMIM |
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CCDS |
CCDS72436
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HPRD |
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IMGT |
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EMBL |
BC027010
M14674
M15442
M16472
M37329
M37330
M37331
M37332
M37333
M37334
M37335
X06375
X07215
X07216
X07217
X07218
X07219
X07220
X07221
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GenPept |
AAA39950
AAA39951
AAA39952
AAA39953
AAA39954
AAA39955
AAH27010
CAA30184
CAB40821
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