InnateDB Protein
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IDBP-254672.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Traf1
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Protein Name
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TNF receptor-associated factor 1
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Synonyms
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4732496E14Rik;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000108687
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InnateDB Gene
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IDBG-163730 (Traf1)
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Protein Structure
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Function |
Adapter molecule that regulates the activation of NF- kappa-B and JNK. Plays a role in the regulation of cell survival and apoptosis. The heterotrimer formed by TRAF1 and TRAF2 is part of a E3 ubiquitin-protein ligase complex that promotes ubiquitination of target proteins, such as MAP3K14. The TRAF1/TRAF2 complex recruits the antiapoptotic E3 protein- ubiquitin ligases BIRC2 and BIRC3 to TNFRSF1B/TNFR2 (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cytoplasm.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 80 interaction(s) predicted by orthology.
Experimentally validated |
Total |
39
[view]
|
Protein-Protein |
39
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
80 [view]
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|
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:101836
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InterPro |
IPR002083
MATH
IPR008974
TRAF-like
IPR012227
TNF receptor-associated factor TRAF
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PFAM |
PF00917
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PRINTS |
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PIRSF |
PIRSF015614
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SMART |
SM00061
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TIGRFAMs |
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Modification |
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SwissProt |
P39428
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PhosphoSite |
PhosphoSite-P39428
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
22029
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UniGene |
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RefSeq |
NP_033447
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MGI ID |
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MGI Symbol |
Traf1
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OMIM |
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CCDS |
CCDS15956
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HPRD |
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IMGT |
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EMBL |
AK029135
AK169515
AK172598
AL929068
CH466542
L35302
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GenPept |
AAC37663
BAC26315
BAE41205
BAE43086
CAM27599
EDL08637
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