InnateDB Protein
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IDBP-254692.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Shroom3
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Protein Name
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shroom family member 3
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Synonyms
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AL022960; D5Ertd287e; Shrm; Shrm3;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000108677
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InnateDB Gene
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IDBG-180434 (Shroom3)
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Protein Structure
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Function |
Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers. Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays. {ECO:0000269PubMed:10589677, ECO:0000269PubMed:14680628, ECO:0000269PubMed:16249236, ECO:0000269PubMed:16684770}.
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Subcellular Localization |
Cell junction, adherens junction {ECO:0000269PubMed:10589677}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:10589677}. Note=Colocalizes with F-actin in stress fibers and adherens junctions.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
3 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1351655
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InterPro |
IPR014799
Apx/shroom, ASD2
IPR014800
Apx/shroom, ASD1
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PFAM |
PF08687
PF08688
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9QXN0
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PhosphoSite |
PhosphoSite-Q9QXN0
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TrEMBL |
G3UXH3
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UniProt Splice Variant |
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Entrez Gene |
27428
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UniGene |
Mm.46014
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RefSeq |
NP_001071063
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MGI ID |
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MGI Symbol |
Shroom3
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OMIM |
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CCDS |
CCDS39155
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HPRD |
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IMGT |
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EMBL |
AC124560
AC125038
AC125233
AF199421
AF199422
AK129371
AK147493
AK164918
BC003909
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GenPept |
AAF13269
AAF13270
AAH03909
BAC98181
BAE27948
BAE37966
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