Version 5.4
Mus musculus Protein: Shroom3
Summary
InnateDB Protein IDBP-254694.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Shroom3
Protein Name shroom family member 3
Synonyms AL022960; D5Ertd287e; Shrm; Shrm3;
Species Mus musculus
Ensembl Protein ENSMUSP00000108674
InnateDB Gene IDBG-180434 (Shroom3)
Protein Structure
UniProt Annotation
Function Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers. Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays. {ECO:0000269PubMed:10589677, ECO:0000269PubMed:14680628, ECO:0000269PubMed:16249236, ECO:0000269PubMed:16684770}.
Subcellular Localization Cell junction, adherens junction {ECO:0000269PubMed:10589677}. Cytoplasm, cytoskeleton {ECO:0000269PubMed:10589677}. Note=Colocalizes with F-actin in stress fibers and adherens junctions.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
Biological Process
GO:0000902 cell morphogenesis
GO:0001843 neural tube closure
GO:0002066 columnar/cuboidal epithelial cell development
GO:0007389 pattern specification process
GO:0008360 regulation of cell shape
GO:0030036 actin cytoskeleton organization
GO:0043482 cellular pigment accumulation
GO:0045176 apical protein localization
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005874 microtubule
GO:0005912 adherens junction
GO:0016324 apical plasma membrane
GO:0043296 apical junction complex
GO:0045177 apical part of cell
Protein Structure and Domains
PDB ID MGI:1351655
InterPro IPR014799 Apx/shroom, ASD2
IPR014800 Apx/shroom, ASD1
PFAM PF08687
PF08688
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9QXN0
PhosphoSite PhosphoSite-Q9QXN0
TrEMBL G3UXH3
UniProt Splice Variant
Entrez Gene 27428
UniGene Mm.46014
RefSeq NP_001071064
MGI ID
MGI Symbol Shroom3
OMIM
CCDS CCDS39155
HPRD
IMGT
EMBL AC124560 AC125038 AC125233 AF199421 AF199422 AK129371 AK147493 AK164918 BC003909
GenPept AAF13269 AAF13270 AAH03909 BAC98181 BAE27948 BAE37966

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca