InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cnot6l

Summary

InnateDB Protein

IDBP-254781.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cnot6l

Protein Name

CCR4-NOT transcription complex, subunit 6-like

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000108629

InnateDB Gene

IDBG-181254 (Cnot6l)

Protein Structure

UniProt Annotation

Function

Poly(A) nuclease with 3'-5' RNase activity. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Involved in mRNA decay mediated by the major-protein- coding determinant of instability (mCRD) of the FOS gene in the cytoplasm. Involved in deadenylation-dependent degradation of CDKN1B mRNA. Its mRNA deadenylase activity can be inhibited by TOB1. Mediates cell proliferation and cell survival and prevents cellular senescence (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
They are also associated with 22 interaction(s) predicted by orthology.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	22 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004535	poly(A)-specific ribonuclease activity
GO:0005515	protein binding
GO:0046872	metal ion binding

Biological Process

GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006397	mRNA processing
GO:0006417	regulation of translation
GO:0008284	positive regulation of cell proliferation
GO:0010606	positive regulation of cytoplasmic mRNA processing body assembly
GO:0031047	gene silencing by RNA
GO:0061157	mRNA destabilization
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic