InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Acsl4

Summary

InnateDB Protein

IDBP-254984.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Acsl4

Protein Name

acyl-CoA synthetase long-chain family member 4

Synonyms

9430020A05Rik; ACS4; AU018108; Facl4; Lacs4;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000108528

InnateDB Gene

IDBG-176201 (Acsl4)

Protein Structure

UniProt Annotation

Function

Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses arachidonate and eicosapentaenoate as substrates.

Subcellular Localization

Mitochondrion outer membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Peroxisome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Abundant in steroidogenic tissues, also found in the kidney, brain and liver.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004467	long-chain fatty acid-CoA ligase activity
GO:0005524	ATP binding
GO:0031957	very long-chain fatty acid-CoA ligase activity
GO:0047676	arachidonate-CoA ligase activity

Biological Process

GO:0001676	long-chain fatty acid metabolic process
GO:0006641	triglyceride metabolic process
GO:0007584	response to nutrient
GO:0008152	metabolic process
GO:0008610	lipid biosynthetic process
GO:0015908	fatty acid transport
GO:0019217	regulation of fatty acid metabolic process
GO:0030182	neuron differentiation
GO:0030307	positive regulation of cell growth
GO:0032307	negative regulation of prostaglandin secretion
GO:0060136	embryonic process involved in female pregnancy
GO:0060996	dendritic spine development
GO:0070672	response to interleukin-15

Cellular Component

GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005778	peroxisomal membrane
GO:0005789	endoplasmic reticulum membrane
GO:0005811	lipid particle
GO:0016021	integral component of membrane
GO:0043025	neuronal cell body