InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Acsl4

Summary

InnateDB Gene

IDBG-176201.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Acsl4

Gene Name

acyl-CoA synthetase long-chain family member 4

Synonyms

9430020A05Rik; ACS4; AU018108; Facl4; Lacs4

Species

Mus musculus

Ensembl Gene

ENSMUSG00000031278

Encoded Proteins

IDBP-176203

acyl-CoA synthetase long-chain family member 4

IDBP-254984

acyl-CoA synthetase long-chain family member 4

IDBP-254986

acyl-CoA synthetase long-chain family member 4

IDBP-254988

acyl-CoA synthetase long-chain family member 4

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000068366:
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme preferentially utilizes arachidonate as substrate. The absence of this enzyme may contribute to the mental retardation or Alport syndrome. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:142317993-142390535

Strand

Reverse strand

Band

Transcripts

ENSMUST00000033634	ENSMUSP00000033634
ENSMUST00000112907	ENSMUSP00000108528
ENSMUST00000112904	ENSMUSP00000108525
ENSMUST00000112903	ENSMUSP00000108524
ENSMUST00000140520

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004467	long-chain fatty acid-CoA ligase activity
GO:0005524	ATP binding
GO:0031957	very long-chain fatty acid-CoA ligase activity
GO:0047676	arachidonate-CoA ligase activity

Biological Process

GO:0001676	long-chain fatty acid metabolic process
GO:0006629	lipid metabolic process
GO:0006641	triglyceride metabolic process
GO:0007584	response to nutrient
GO:0008152	metabolic process
GO:0008610	lipid biosynthetic process
GO:0015908	fatty acid transport
GO:0019217	regulation of fatty acid metabolic process
GO:0030182	neuron differentiation
GO:0030307	positive regulation of cell growth
GO:0032307	negative regulation of prostaglandin secretion
GO:0060136	embryonic process involved in female pregnancy
GO:0060996	dendritic spine development
GO:0070672	response to interleukin-15

Cellular Component

GO:0005737	cytoplasm
GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005777	peroxisome
GO:0005778	peroxisomal membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005811	lipid particle
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031966	mitochondrial membrane
GO:0043025	neuronal cell body
GO:0070062	extracellular vesicular exosome