InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ALDOA

Summary

InnateDB Protein

IDBP-25502.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ALDOA

Protein Name

aldolase A, fructose-bisphosphate

Synonyms

ALDA; GSD12; HEL-S-87p;

Species

Homo sapiens

Ensembl Protein

ENSP00000336927

InnateDB Gene

IDBG-25500 (ALDOA)

Protein Structure

UniProt Annotation

Function

Plays a key role in glycolysis and gluconeogenesis. In addition, may also function as scaffolding protein (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, myofibril, sarcomere, I band. Cytoplasm, myofibril, sarcomere, M line. Note=In skeletal muscle, accumulates around the M line and within the I band, colocalizing with FBP2 on both sides of the Z line in the absence of Ca(2+). {ECO:0000250}.

Disease Associations

Glycogen storage disease 12 (GSD12) [MIM:611881]: A metabolic disorder associated with increased hepatic glycogen and hemolytic anemia. It may lead to myopathy with exercise intolerance and rhabdomyolysis. {ECO:0000269PubMed:14615364, ECO:0000269PubMed:14766013, ECO:0000269PubMed:2825199, ECO:0000269PubMed:8598869}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 63 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	63 [view]
Protein-Protein	62 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0004332	fructose-bisphosphate aldolase activity
GO:0005515	protein binding
GO:0008092	cytoskeletal protein binding
GO:0015631	tubulin binding
GO:0042802	identical protein binding
GO:0044822	poly(A) RNA binding
GO:0070061	fructose binding

Biological Process

GO:0002576	platelet degranulation
GO:0005975	carbohydrate metabolic process
GO:0006000	fructose metabolic process
GO:0006006	glucose metabolic process
GO:0006094	gluconeogenesis
GO:0006096	glycolytic process
GO:0006754	ATP biosynthetic process
GO:0006941	striated muscle contraction
GO:0007015	actin filament organization
GO:0007596	blood coagulation
GO:0008360	regulation of cell shape
GO:0030168	platelet activation
GO:0030388	fructose 1,6-bisphosphate metabolic process
GO:0044281	small molecule metabolic process
GO:0046716	muscle cell cellular homeostasis
GO:0051289	protein homotetramerization

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005829	cytosol
GO:0015629	actin cytoskeleton
GO:0016020	membrane
GO:0031093	platelet alpha granule lumen
GO:0031430	M band
GO:0031674	I band
GO:0070062	extracellular vesicular exosome