Version 5.4
Mus musculus Protein: Nck1
Summary
InnateDB Protein IDBP-255064.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Nck1
Protein Name non-catalytic region of tyrosine kinase adaptor protein 1
Synonyms 6330586M15Rik; D230010O13Rik; Nck; Nck-1;
Species Mus musculus
Ensembl Protein ENSMUSP00000108495
InnateDB Gene IDBG-193200 (Nck1)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 209 interaction(s) predicted by orthology.
Experimentally validated
Total 29 [view]
Protein-Protein 29 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 209 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0016301 kinase activity
GO:0019887 protein kinase regulator activity
GO:0019904 protein domain specific binding
Biological Process
GO:0007015 actin filament organization
GO:0016310 phosphorylation
GO:0016477 cell migration
GO:0030032 lamellipodium assembly
GO:0030838 positive regulation of actin filament polymerization
GO:0045859 regulation of protein kinase activity
GO:0051707 response to other organism
Cellular Component
GO:0005911 cell-cell junction
GO:0012506 vesicle membrane
Protein Structure and Domains
PDB ID MGI:109601
InterPro IPR000980 SH2 domain
IPR001452 SH3 domain
IPR011511 Variant SH3 domain
PFAM PF00017
PF14633
PF00018
PF14604
PF07653
PRINTS PR00401
PR00452
PIRSF
SMART SM00252
SM00326
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q8BZ27
UniProt Splice Variant
Entrez Gene 17973
UniGene Mm.402588
RefSeq XP_006510904
MGI ID
MGI Symbol Nck1
OMIM
CCDS
HPRD
IMGT
EMBL AC129223 AK036870 AK053155 AK054051 CH466560
GenPept BAC29611 BAC35286 BAC35635 EDL21030

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca