Version 5.4
Mus musculus Gene: Nck1
Summary
InnateDB Gene IDBG-193200.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nck1
Gene Name non-catalytic region of tyrosine kinase adaptor protein 1
Synonyms 6330586M15Rik; D230010O13Rik; Nck; Nck-1
Species Mus musculus
Ensembl Gene ENSMUSG00000032475
Encoded Proteins
IDBP-255064
non-catalytic region of tyrosine kinase adaptor protein 1
IDBP-273916
non-catalytic region of tyrosine kinase adaptor protein 1
IDBP-788486
non-catalytic region of tyrosine kinase adaptor protein 1
IDBP-788487
non-catalytic region of tyrosine kinase adaptor protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000158092:
The protein encoded by this gene is one of the signaling and transforming proteins containing Src homology 2 and 3 (SH2 and SH3) domains. It is located in the cytoplasm and is an adaptor protein involved in transducing signals from receptor tyrosine kinases to downstream signal recipients such as RAS. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:100492293-100546134
Strand Reverse strand
Band E3.3
Transcripts
ENSMUST00000112874 ENSMUSP00000108495
ENSMUST00000116522 ENSMUSP00000112221
ENSMUST00000186591 ENSMUSP00000140971
ENSMUST00000188670 ENSMUSP00000140143
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 29 experimentally validated interaction(s) in this database.
They are also associated with 209 interaction(s) predicted by orthology.
Experimentally validated
Total 29 [view]
Protein-Protein 29 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 209 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004860 protein kinase inhibitor activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0016301 kinase activity
GO:0019887 protein kinase regulator activity
GO:0019904 protein domain specific binding
GO:0030971 receptor tyrosine kinase binding
Biological Process
GO:0006417 regulation of translation
GO:0006469 negative regulation of protein kinase activity
GO:0007015 actin filament organization
GO:0016310 phosphorylation
GO:0016477 cell migration
GO:0030032 lamellipodium assembly
GO:0030838 positive regulation of actin filament polymerization
GO:0042102 positive regulation of T cell proliferation
GO:0042110 T cell activation
GO:0045859 regulation of protein kinase activity
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051707 response to other organism
GO:0060548 negative regulation of cell death
Cellular Component
GO:0005634 nucleus
GO:0005783 endoplasmic reticulum
GO:0005911 cell-cell junction
GO:0012506 vesicle membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000158092
View Gene Order
ENSBTAG00000018427
Not yet available
Pathways
NETPATH
REACTOME
REACT_239142
Innate Immune System pathway
REACT_198374
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_188199
Signaling by the B Cell Receptor (BCR) pathway
REACT_188194
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
REACT_257032
Nephrin interactions pathway
REACT_229826
Netrin-1 signaling pathway
REACT_227951
Signaling by VEGF pathway
REACT_230745
Immune System pathway
REACT_230639
Downstream signal transduction pathway
REACT_221567
Signaling by Robo receptor pathway
REACT_248291
DCC mediated attractive signaling pathway
REACT_257088
VEGFA-VEGFR2 Pathway pathway
REACT_261444
Axon guidance pathway
REACT_209368
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_229531
Adaptive Immune System pathway
REACT_263353
Signaling by PDGF pathway
REACT_188576
Developmental Biology pathway
REACT_188257
Signal Transduction pathway
REACT_225768
Generation of second messenger molecules pathway
REACT_223082
Cell-Cell communication pathway
REACT_260744
Activation of Rac pathway
REACT_222648
TCR signaling pathway
KEGG
mmu04360
Axon guidance pathway
mmu04012
ErbB signaling pathway pathway
mmu04660
T cell receptor signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
NetPath_4
EGFR1 pathway
NetPath_11
TCR pathway
NetPath_12
BCR pathway
NetPath_56
Prolactin pathway
REACTOME
REACT_160086
Regulation of actin dynamics for phagocytic cup formation pathway
REACT_12623
Generation of second messenger molecules pathway
REACT_118700
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_23832
Nephrin interactions pathway
REACT_22351
DCC mediated attractive signaling pathway
REACT_22237
Netrin-1 signaling pathway
REACT_19226
Activation of Rac pathway
REACT_19351
Signaling by Robo receptor pathway
REACT_111045
Developmental Biology pathway
REACT_111155
Cell-Cell communication pathway
REACT_12526
TCR signaling pathway
REACT_12529
Signaling by VEGF pathway
REACT_6802
Innate Immune System pathway
REACT_18266
Axon guidance pathway
REACT_111102
Signal Transduction pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
REACT_160123
Fcgamma receptor (FCGR) dependent phagocytosis pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
KEGG
hsa05130
Pathogenic Escherichia coli infection pathway
hsa04012
ErbB signaling pathway pathway
hsa04360
Axon guidance pathway
hsa04660
T cell receptor signaling pathway pathway
INOH
INOH website
PDGF signaling pathway pathway
PID NCI
netrin_pathway
Netrin-mediated signaling events
tcr_pathway
TCR signaling in naïve CD4+ T cells
ephbfwdpathway
EPHB forward signaling
angiopoietinreceptor_pathway
Angiopoietin receptor Tie2-mediated signaling
ret_pathway
Signaling events regulated by Ret tyrosine kinase
vegfr1_pathway
VEGFR1 specific signals
ecadherin_stabilization_pathway
Stabilization and expansion of the E-cadherin adherens junction
arf6_pathway
Arf6 signaling events
insulin_pathway
Insulin Pathway
Cross-References
SwissProt Q99M51
TrEMBL Q8BH99 Q8BZ27
UniProt Splice Variant
Entrez Gene 17973
UniGene Mm.181485 Mm.367797 Mm.402588
RefSeq NM_010878 XM_006510840 XM_006510841
OMIM
CCDS CCDS23440
HPRD
IMGT
MGI ID MGI:109601
MGI Symbol Nck1
EMBL AC129223 AF043259 AF084183 AK036870 AK053155 AK054051 BC002015 CH466560
GenPept AAC06352 AAD13752 AAH02015 BAC29611 BAC35286 BAC35635 EDL21028 EDL21029 EDL21030 EDL21031
RNA Seq Atlas 17973

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca