InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: STEAP4

Summary

InnateDB Protein

IDBP-25514.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STEAP4

Protein Name

STEAP family member 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000305545

InnateDB Gene

IDBG-25512 (STEAP4)

Protein Structure

UniProt Annotation

Function

Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance. Involved in inflammatory arthritis, through the regulation of inflammatory cytokines. Inhibits anchorage-independent cell proliferation. {ECO:0000250, ECO:0000269PubMed:18381574, ECO:0000269PubMed:18430367, ECO:0000269PubMed:19660107, ECO:0000269PubMed:19787193}.

Subcellular Localization

Cell membrane. Golgi apparatus membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Ubiquitous. Highly expressed in adipose tissue. Expressed in placenta, lung, heart and prostate. Detected at lower levels in liver, skeletal muscle, pancreas, testis and small intestine. Highly expressed in joints of patients with rheumatoid arthritis and localized with CD68 cells, a marker for macrophages. {ECO:0000269PubMed:15897894, ECO:0000269PubMed:16227996, ECO:0000269PubMed:18381574, ECO:0000269PubMed:18430367, ECO:0000269PubMed:19289123, ECO:0000269PubMed:19660107}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004616	phosphogluconate dehydrogenase (decarboxylating) activity
GO:0016491	oxidoreductase activity
GO:0046872	metal ion binding

Biological Process

GO:0006098	pentose-phosphate shunt
GO:0006811	ion transport
GO:0045444	fat cell differentiation
GO:0055072	iron ion homeostasis
GO:0055114	oxidation-reduction process

Cellular Component

GO:0000139	Golgi membrane
GO:0005886	plasma membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR006115 6-phosphogluconate dehydrogenase, NADP-binding
IPR013130 Ferric reductase transmembrane component-like domain
IPR028939 Pyrroline-5-carboxylate reductase, catalytic, N-terminal

PFAM

PF03446
PF01794
PF03807

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q687X5

PhosphoSite