Version 5.4
Homo sapiens Gene: STEAP4
Summary
InnateDB Gene IDBG-25512.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STEAP4
Gene Name STEAP family member 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000127954
Encoded Proteins
IDBP-25514
STEAP family member 4
IDBP-25516
STEAP family member 4
IDBP-381193
STEAP family member 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the STEAP (six transmembrane epithelial antigen of prostate) family, and resides in the golgi apparatus. It functions as a metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+), using NAD(+) as acceptor. Studies in mice and human suggest that this gene maybe involved in adipocyte development and metabolism, and may contribute to the normal biology of the prostate cell, as well as prostate cancer progression. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:88276429-88306891
Strand Reverse strand
Band q21.12
Transcripts
ENST00000301959 ENSP00000305545
ENST00000380079 ENSP00000369419
ENST00000414498 ENSP00000394399
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004616 phosphogluconate dehydrogenase (decarboxylating) activity
GO:0008823 cupric reductase activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
GO:0052851 ferric-chelate reductase (NADPH) activity
Biological Process
GO:0006098 pentose-phosphate shunt
GO:0006811 ion transport
GO:0015677 copper ion import
GO:0045444 fat cell differentiation
GO:0055072 iron ion homeostasis
GO:0055114 oxidation-reduction process
GO:0097461 ferric iron import into cell
Cellular Component
GO:0000139 Golgi membrane
GO:0005768 endosome
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000012428
View Gene Order
ENSBTAG00000002340
Not yet available
Cross-References
SwissProt Q687X5
TrEMBL C9JS50
UniProt Splice Variant
Entrez Gene 79689
UniGene Hs.521008 Hs.622049 Hs.710760
RefSeq NM_001205315 NM_001205316 NM_024636
HUGO HGNC:21923
OMIM 611098
CCDS CCDS43611 CCDS56494
HPRD
IMGT
EMBL AC003991 AF423422 AF423423 AK026806 AL833044 BC020600
GenPept AAH20600 AAQ04063 AAQ04064 BAB15559 CAH56271
RNA Seq Atlas 79689

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca