InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: STEAP4

Summary

InnateDB Protein

IDBP-25516.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STEAP4

Protein Name

STEAP family member 4

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000369419

InnateDB Gene

IDBG-25512 (STEAP4)

Protein Structure

UniProt Annotation

Function

Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor. Plays a role in systemic metabolic homeostasis, integrating inflammatory and metabolic responses (By similarity). Associated with obesity and insulin-resistance. Involved in inflammatory arthritis, through the regulation of inflammatory cytokines. Inhibits anchorage-independent cell proliferation. {ECO:0000250, ECO:0000269PubMed:18381574, ECO:0000269PubMed:18430367, ECO:0000269PubMed:19660107, ECO:0000269PubMed:19787193}.

Subcellular Localization

Cell membrane. Golgi apparatus membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Ubiquitous. Highly expressed in adipose tissue. Expressed in placenta, lung, heart and prostate. Detected at lower levels in liver, skeletal muscle, pancreas, testis and small intestine. Highly expressed in joints of patients with rheumatoid arthritis and localized with CD68 cells, a marker for macrophages. {ECO:0000269PubMed:15897894, ECO:0000269PubMed:16227996, ECO:0000269PubMed:18381574, ECO:0000269PubMed:18430367, ECO:0000269PubMed:19289123, ECO:0000269PubMed:19660107}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0008823	cupric reductase activity
GO:0016491	oxidoreductase activity
GO:0046872	metal ion binding
GO:0052851	ferric-chelate reductase (NADPH) activity

Biological Process

GO:0006811	ion transport
GO:0015677	copper ion import
GO:0045444	fat cell differentiation
GO:0055072	iron ion homeostasis
GO:0055114	oxidation-reduction process
GO:0097461	ferric iron import into cell