InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Serpinb5

Summary

InnateDB Protein

IDBP-255391.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Serpinb5

Protein Name

serine (or cysteine) peptidase inhibitor, clade B, member 5

Synonyms

1110036M19Rik; AI462524; AI646751; Maspin; ovalbumin; PI-5; Spi7;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000108350

InnateDB Gene

IDBG-185824 (Serpinb5)

Protein Structure

UniProt Annotation

Function

Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004867	serine-type endopeptidase inhibitor activity

Biological Process

GO:0002009	morphogenesis of an epithelium
GO:0010951	negative regulation of endopeptidase activity
GO:0030162	regulation of proteolysis
GO:0030198	extracellular matrix organization
GO:0050678	regulation of epithelial cell proliferation
GO:0060512	prostate gland morphogenesis