InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Serpinb5

Summary

InnateDB Protein

IDBP-255393.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Serpinb5

Protein Name

serine (or cysteine) peptidase inhibitor, clade B, member 5

Synonyms

1110036M19Rik; AI462524; AI646751; Maspin; ovalbumin; PI-5; Spi7;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000108349

InnateDB Gene

IDBG-185824 (Serpinb5)

Protein Structure

UniProt Annotation

Function

Tumor suppressor. It blocks the growth, invasion, and metastatic properties of mammary tumors. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004867	serine-type endopeptidase inhibitor activity

Biological Process

GO:0002009	morphogenesis of an epithelium
GO:0010951	negative regulation of endopeptidase activity
GO:0030162	regulation of proteolysis
GO:0030198	extracellular matrix organization
GO:0050678	regulation of epithelial cell proliferation
GO:0060512	prostate gland morphogenesis

Cellular Component

GO:0005615	extracellular space
GO:0005737	cytoplasm

Protein Structure and Domains

PDB ID

MGI:109579

InterPro

IPR000240 Serpin B9/maspin
IPR023796 Serpin domain

PFAM

PF00079

PRINTS

PR00676

PIRSF

SMART

SM00093

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P70124

PhosphoSite

PhosphoSite-

TrEMBL

UniProt Splice Variant

Entrez Gene

20724

UniGene

Mm.436502

RefSeq

MGI ID

MGI Symbol

Serpinb5

OMIM

CCDS

CCDS35684

HPRD

IMGT

EMBL

AK136532 AK145220 BC005434 CH466520 U54705

GenPept

AAB06042 AAH05434 BAE23032 BAE26308 EDL39856 EDL39857