InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TPO

Summary

InnateDB Protein

IDBP-25542.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TPO

Protein Name

thyroid peroxidase

Synonyms

MSA; TDH2A; TPX;

Species

Homo sapiens

Ensembl Protein

ENSP00000371636

InnateDB Gene

IDBG-25524 (TPO)

Protein Structure

UniProt Annotation

Function

Iodination and coupling of the hormonogenic tyrosines in thyroglobulin to yield the thyroid hormones T(3) and T(4).

Subcellular Localization

Membrane; Single-pass type I membrane protein.Isoform 3: Cell surface.

Disease Associations

Note=An alternative splicing in the thyroperoxidase mRNA can cause Graves' disease.Thyroid dyshormonogenesis 2A (TDH2A) [MIM:274500]: A disorder due to defective conversion of accumulated iodide to organically bound iodine. The iodide organification defect can be partial or complete. {ECO:0000269PubMed:10084596, ECO:0000269PubMed:10468986, ECO:0000269PubMed:11061528, ECO:0000269PubMed:11415848, ECO:0000269PubMed:11874711, ECO:0000269PubMed:11916616, ECO:0000269PubMed:12213873, ECO:0000269PubMed:12490071, ECO:0000269PubMed:12843174, ECO:0000269PubMed:12864797, ECO:0000269PubMed:12938097, ECO:0000269PubMed:16284446, ECO:0000269PubMed:16684826, ECO:0000269PubMed:7550241, ECO:0000269PubMed:9024270, ECO:0000269PubMed:9924196}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004447	iodide peroxidase activity
GO:0004601	peroxidase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0020037	heme binding

Biological Process

GO:0006590	thyroid hormone generation
GO:0006979	response to oxidative stress
GO:0034641	cellular nitrogen compound metabolic process
GO:0035162	embryonic hemopoiesis
GO:0042446	hormone biosynthetic process
GO:0042744	hydrogen peroxide catabolic process
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009986	cell surface

Protein Structure and Domains

PDB ID

InterPro

IPR000436 Sushi/SCR/CCP
IPR000742 Epidermal growth factor-like domain
IPR001881 EGF-like calcium-binding domain
IPR010255 Haem peroxidase
IPR019791 Haem peroxidase, animal

PFAM

PF00084
PF00008
PF07645
PF03098

PRINTS

PR00457

PIRSF

SMART

SM00032
SM00181
SM00179

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt