InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rif1

Summary

InnateDB Protein

IDBP-255468.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rif1

Protein Name

Rap1 interacting factor 1 homolog (yeast)

Synonyms

5730435J01Rik; 6530403D07Rik; AU016181; AW549474; D2Ertd145e;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000108313

InnateDB Gene

IDBG-169383 (Rif1)

Protein Structure

UniProt Annotation

Function

Required for checkpoint mediated arrest of cell cycle progression in response to DNA damage during S-phase (the intra-S- phase checkpoint). This checkpoint requires activation of at least 2 parallel pathways by the ATM kinase: one involves the MRN (MRE11A-RAD50-NBS1) complex, while the second requires CHEK2. RIF1 seems to act independently of both these pathways. Seems to play no role in either the G1/S or G2/M DNA damage checkpoints (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:15042697}. Chromosome, telomere {ECO:0000269PubMed:15042697}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}. Note=Exhibits ATM- and TP53BP1-dependent localization to uncapped or aberrant telomeres and to DNA double strand breaks (DSBs). Localizes to microtubules of the midzone of the mitotic spindle during anaphase, and to condensed chromosomes in telophase (By similarity). While the majority of the protein appears nuclear and distinct from normal telomere structures, a small fraction may bind to telomeres in embryonic stem cells. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in Sertoli cells, prospermatagonia, early primary spermatocytes, and in oocytes at all stages of their growth. Expressed in embryonic stem (ES) and embryonic germ (EG) cells: expression is lost upon differentiation. {ECO:0000269PubMed:15042697}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
They are also associated with 105 interaction(s) predicted by orthology.

Experimentally validated
Total	11 [view]
Protein-Protein	11 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	105 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005488	binding
GO:0005515	protein binding

Biological Process

GO:0006974	cellular response to DNA damage stimulus
GO:0007049	cell cycle
GO:0019827	stem cell maintenance

Cellular Component

GO:0000781	chromosome, telomeric region
GO:0001939	female pronucleus
GO:0001940	male pronucleus
GO:0005634	nucleus
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005819	spindle
GO:0005886	plasma membrane