Version 5.4
Mus musculus Protein: Nr4a2
Summary
InnateDB Protein IDBP-255622.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Nr4a2
Protein Name nuclear receptor subfamily 4, group A, member 2
Synonyms HZF-3; NOT; Nurr1; RNR-1; TINOR; TINUR;
Species Mus musculus
Ensembl Protein ENSMUSP00000108246
InnateDB Gene IDBG-171511 (Nr4a2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 7 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 25 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0001666 response to hypoxia
GO:0001764 neuron migration
GO:0001975 response to amphetamine
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007399 nervous system development
GO:0008344 adult locomotory behavior
GO:0009791 post-embryonic development
GO:0010035 response to inorganic substance
GO:0010467 gene expression
GO:0010468 regulation of gene expression
GO:0016265 death
GO:0017085 response to insecticide
GO:0021952 central nervous system projection neuron axonogenesis
GO:0021953 central nervous system neuron differentiation
GO:0021986 habenula development
GO:0030182 neuron differentiation
GO:0030522 intracellular receptor signaling pathway
GO:0031668 cellular response to extracellular stimulus
GO:0034599 cellular response to oxidative stress
GO:0042053 regulation of dopamine metabolic process
GO:0042416 dopamine biosynthetic process
GO:0042417 dopamine metabolic process
GO:0042551 neuron maturation
GO:0043085 positive regulation of catalytic activity
GO:0043401 steroid hormone mediated signaling pathway
GO:0043524 negative regulation of neuron apoptotic process
GO:0043576 regulation of respiratory gaseous exchange
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051866 general adaptation syndrome
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:1352456
InterPro IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001628 Zinc finger, nuclear hormone receptor-type
IPR001723 Steroid hormone receptor
IPR003070 Orphan nuclear receptor
IPR003073 Orphan nuclear receptor, NURR type
IPR003078 Retinoic acid receptor
IPR008946 Nuclear hormone receptor, ligand-binding
PFAM PF00104
PF00105
PRINTS PR00047
PR00398
PR01284
PR01287
PR01292
PIRSF
SMART SM00430
SM00399
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL A2AQQ8
UniProt Splice Variant
Entrez Gene 18227
UniGene Mm.420796
RefSeq
MGI ID
MGI Symbol Nr4a2
OMIM
CCDS
HPRD
IMGT
EMBL AL844871
GenPept

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca