Version 5.4
Mus musculus Gene: Nr4a2
Summary
InnateDB Gene IDBG-171511.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Nr4a2
Gene Name nuclear receptor subfamily 4, group A, member 2
Synonyms HZF-3; NOT; Nurr1; RNR-1; TINOR; TINUR
Species Mus musculus
Ensembl Gene ENSMUSG00000026826
Encoded Proteins
IDBP-171515
nuclear receptor subfamily 4, group A, member 2
IDBP-255620
nuclear receptor subfamily 4, group A, member 2
IDBP-255622
nuclear receptor subfamily 4, group A, member 2
IDBP-790236
nuclear receptor subfamily 4, group A, member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000153234:
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:57106830-57124003
Strand Reverse strand
Band C1.1
Transcripts
ENSMUST00000028166 ENSMUSP00000028166
ENSMUST00000112629 ENSMUSP00000108248
ENSMUST00000112627 ENSMUSP00000108246
ENSMUST00000140165
ENSMUST00000128776
ENSMUST00000183542 ENSMUSP00000138824
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 25 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 7 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 25 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0001228 RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003707 steroid hormone receptor activity
GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0001666 response to hypoxia
GO:0001764 neuron migration
GO:0001975 response to amphetamine
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007399 nervous system development
GO:0008344 adult locomotory behavior
GO:0009791 post-embryonic development
GO:0010035 response to inorganic substance
GO:0010467 gene expression
GO:0010468 regulation of gene expression
GO:0016265 death
GO:0017085 response to insecticide
GO:0021952 central nervous system projection neuron axonogenesis
GO:0021953 central nervous system neuron differentiation
GO:0021986 habenula development
GO:0030182 neuron differentiation
GO:0030522 intracellular receptor signaling pathway
GO:0031668 cellular response to extracellular stimulus
GO:0034599 cellular response to oxidative stress
GO:0042053 regulation of dopamine metabolic process
GO:0042416 dopamine biosynthetic process
GO:0042417 dopamine metabolic process
GO:0042551 neuron maturation
GO:0043085 positive regulation of catalytic activity
GO:0043401 steroid hormone mediated signaling pathway
GO:0043524 negative regulation of neuron apoptotic process
GO:0043576 regulation of respiratory gaseous exchange
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051866 general adaptation syndrome
GO:0071542 dopaminergic neuron differentiation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000153234
View Gene Order
ENSBTAG00000003650
Not yet available
Pathways
NETPATH
REACTOME
REACT_234105
Nuclear Receptor transcription pathway pathway
REACT_233572
Gene Expression pathway
REACT_206529
Generic Transcription Pathway pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_15525
Nuclear Receptor transcription pathway pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_71
Gene Expression pathway
REACT_227938
Generic Transcription Pathway pathway
REACT_226022
Gene Expression pathway
REACT_210423
Nuclear Receptor transcription pathway pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.3507 Mm.406232 Mm.420796
RefSeq NM_001139509 NM_013613
OMIM
CCDS CCDS16043
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca