InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Glis3

Summary

InnateDB Protein

IDBP-255649.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Glis3

Protein Name

GLIS family zinc finger 3

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000108231

InnateDB Gene

IDBG-156463 (Glis3)

Protein Structure

UniProt Annotation

Function

Acts as both a repressor and activator of transcription. Binds to the consensus sequence 5'-GACCACCCAC-3'. {ECO:0000269PubMed:14500813}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:14500813}.

Disease Associations

Tissue Specificity

In the embryo, expressed at high levels in the kidney and testis. In the adult, expressed at high levels in the kidney and uterus and at lower levels in the brain, lung, skeletal muscle and pancreas. {ECO:0000269PubMed:14500813}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0046872	metal ion binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0006366	transcription from RNA polymerase II promoter
GO:0045944	positive regulation of transcription from RNA polymerase II promoter