Version 5.4
Mus musculus Gene: Glis3
Summary
InnateDB Gene IDBG-156463.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Glis3
Gene Name GLIS family zinc finger 3
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000052942
Encoded Proteins
IDBP-156465
GLIS family zinc finger 3
IDBP-255649
GLIS family zinc finger 3
IDBP-534145
GLIS family zinc finger 3
IDBP-534176
GLIS family zinc finger 3
IDBP-538054
GLIS family zinc finger 3
IDBP-534673
GLIS family zinc finger 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000107249:
This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear protein with five C2H2-type zinc finger domains. This protein functions as both a repressor and activator of transcription and is specifically involved in the development of pancreatic beta cells, the thyroid, eye, liver and kidney. Mutations in this gene have been associated with neonatal diabetes and congenital hypothyroidism (NDH). Alternatively spliced variants that encode different protein isoforms have been described but the full-length nature of only two have been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:28258851-28680077
Strand Reverse strand
Band C1
Transcripts
ENSMUST00000065113 ENSMUSP00000066953
ENSMUST00000112612 ENSMUSP00000108231
ENSMUST00000162022 ENSMUSP00000124635
ENSMUST00000159520
ENSMUST00000162873
ENSMUST00000161026
ENSMUST00000159639
ENSMUST00000160376 ENSMUSP00000124143
ENSMUST00000161328 ENSMUSP00000125721
ENSMUST00000159178 ENSMUSP00000124823
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005794 Golgi apparatus
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000107249
View Gene Order
ENSBTAG00000014467
Not yet available
Cross-References
SwissProt Q6XP49
TrEMBL E0CX93
UniProt Splice Variant
Entrez Gene 226075
UniGene Mm.223508 Mm.459186
RefSeq NM_175459 XM_006526984 XM_006526985 XM_006526986
OMIM
CCDS CCDS37947
HPRD
IMGT
MGI ID MGI:2444289
MGI Symbol Glis3
EMBL AC116137 AC116863 AC118934 AC161521 AK054020 AY220846
GenPept AAP59883 BAC35623
RNA Seq Atlas 226075

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca