InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pex5

Summary

InnateDB Protein

IDBP-255809.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pex5

Protein Name

peroxisomal biogenesis factor 5

Synonyms

AW212715; ESTM1; PTS1R; Pxr1; X83306;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000108151

InnateDB Gene

IDBG-186793 (Pex5)

Protein Structure

UniProt Annotation

Function

Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import.

Subcellular Localization

Cytoplasm. Peroxisome membrane; Peripheral membrane protein. Note=Its distribution appears to be dynamic. It is probably a cycling receptor found mainly in the cytoplasm and as well associated to the peroxisomal membrane through a docking factor (PEX13).

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 65 interaction(s) predicted by orthology.

Predicted by orthology
Total	65 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000268	peroxisome targeting sequence binding
GO:0005052	peroxisome matrix targeting signal-1 binding
GO:0005515	protein binding
GO:0008022	protein C-terminus binding
GO:0031267	small GTPase binding
GO:0047485	protein N-terminus binding

Biological Process

GO:0000038	very long-chain fatty acid metabolic process
GO:0001764	neuron migration
GO:0006625	protein targeting to peroxisome
GO:0006635	fatty acid beta-oxidation
GO:0007005	mitochondrion organization
GO:0007006	mitochondrial membrane organization
GO:0007029	endoplasmic reticulum organization
GO:0007031	peroxisome organization
GO:0016558	protein import into peroxisome matrix
GO:0016560	protein import into peroxisome matrix, docking
GO:0016561	protein import into peroxisome matrix, translocation
GO:0021795	cerebral cortex cell migration
GO:0021895	cerebral cortex neuron differentiation
GO:0040018	positive regulation of multicellular organism growth
GO:0044255	cellular lipid metabolic process
GO:0045046	protein import into peroxisome membrane
GO:0048468	cell development
GO:0050905	neuromuscular process
GO:0051262	protein tetramerization
GO:1901094	negative regulation of protein homotetramerization

Cellular Component

GO:0005739	mitochondrion
GO:0005777	peroxisome
GO:0005778	peroxisomal membrane
GO:0005782	peroxisomal matrix
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0043234	protein complex