Version 5.4
Mus musculus Protein: Sms
Summary
InnateDB Protein IDBP-255821.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Sms
Protein Name spermine synthase
Synonyms AI427066; Gy; gyro; SpmST; SPMSY;
Species Mus musculus
Ensembl Protein ENSMUSP00000108148
InnateDB Gene IDBG-181702 (Sms)
Protein Structure
UniProt Annotation
Function Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM) (By similarity). Required for normal viability, growth and fertility. {ECO:0000250, ECO:0000269PubMed:15459188}.
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0016768 spermine synthase activity
Biological Process
GO:0006597 spermine biosynthetic process
Cellular Component
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID MGI:109490
InterPro IPR001045 Spermidine/spermine synthases family
IPR029063 S-adenosyl-L-methionine-dependent methyltransferase-like
PFAM PF01564
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt P97355
PhosphoSite PhosphoSite-P97355
TrEMBL A2AC81
UniProt Splice Variant
Entrez Gene 671878
UniGene Mm.462155
RefSeq NP_033240
MGI ID
MGI Symbol Sms
OMIM
CCDS CCDS41189
HPRD
IMGT
EMBL AF031486 AF136179 AJ000087 AJ000088 AJ000089 AJ000090 AJ000091 AJ000092 AJ000093 AK011542 AK017775 AK049787 AK149929 AK160637 AK160659 AK166665 AL663072 BC046623 BC058688 Y09419
GenPept AAB86631 AAD33057 AAH46623 AAH58688 BAB27685 BAB30923 BAC33920 BAE29173 BAE35931 BAE35947 BAE38927 CAA03918 CAA03919 CAA70573 CAM18089

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca