Version 5.4
Mus musculus Protein: Ltbp1
Summary
InnateDB Protein IDBP-255827.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ltbp1
Protein Name latent transforming growth factor beta binding protein 1
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000108135
InnateDB Gene IDBG-198219 (Ltbp1)
Protein Structure
UniProt Annotation
Function May be involved in the assembly, secretion and targeting of TGFB1 to sites at which it is stored and/or activated. May play critical roles in controlling and directing the activity of TGFB1. May have a structural role in the extra cellular matrix (ECM).
Subcellular Localization Secreted {ECO:0000250UniProtKB:Q14766}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0019838 growth factor binding
Biological Process
GO:0007179 transforming growth factor beta receptor signaling pathway
Cellular Component
GO:0005578 proteinaceous extracellular matrix
Protein Structure and Domains
PDB ID MGI:109151
InterPro IPR000742 Epidermal growth factor-like domain
IPR001881 EGF-like calcium-binding domain
IPR017878 TB domain
PFAM PF00008
PF07645
PF00683
PRINTS
PIRSF
SMART SM00181
SM00179
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8CG19
PhosphoSite PhosphoSite-Q8CG19
TrEMBL Q99PJ3
UniProt Splice Variant
Entrez Gene 268977
UniGene Mm.269747
RefSeq NP_996841
MGI ID
MGI Symbol Ltbp1
OMIM
CCDS CCDS37694
HPRD
IMGT
EMBL AC118018 AC126550 AC154178 AC154491 AF022889 AF280604 AF346434 AF346435 AF346436 AF346437 AF346438 AF346439 AF346440 AF346441 AF346442 AF346443 AF346444 AF346445 AF346446 AF346447 AF346448 AF346449 AF346450 AF346451 AF346452 AF346453 AF346454 AF346455 AF346456 AF346457 AF346458 AF346459 AF346460 AF346461 AF346462 AF346463 AF346464 AF346465 AK050380 AK080024 AY143161 BC094612 CT033758
GenPept AAC33307 AAG53890 AAH94612 AAN38831 AAN77250 AAN77251 BAC34222 BAC37808 CAM24102 CAM24103 CAM24104

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca