Version 5.4
Mus musculus Gene: Ltbp1
Summary
InnateDB Gene IDBG-198219.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ltbp1
Gene Name latent transforming growth factor beta binding protein 1
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000001870
Encoded Proteins
IDBP-198221
latent transforming growth factor beta binding protein 1
IDBP-255827
latent transforming growth factor beta binding protein 1
IDBP-255829
latent transforming growth factor beta binding protein 1
IDBP-537180
latent transforming growth factor beta binding protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000049323:
The protein encoded by this gene belongs to the family of latent TGF-beta binding proteins (LTBPs). The secretion and activation of TGF-betas is regulated by their association with latency-associated proteins and with latent TGF-beta binding proteins. The product of this gene targets latent complexes of transforming growth factor beta to the extracellular matrix, where the latent cytokine is subsequently activated by several different mechanisms. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:75005568-75392512
Strand Forward strand
Band E2
Transcripts
ENSMUST00000001927 ENSMUSP00000001927
ENSMUST00000112516 ENSMUSP00000108135
ENSMUST00000112514 ENSMUSP00000108133
ENSMUST00000146839
ENSMUST00000135447 ENSMUSP00000116890
ENSMUST00000127458
ENSMUST00000135750
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0019838 growth factor binding
GO:0050431 transforming growth factor beta binding
Biological Process
GO:0007179 transforming growth factor beta receptor signaling pathway
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0031012 extracellular matrix
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000049323
View Gene Order
ENSBTAG00000019839
Not yet available
Pathways
NETPATH
REACTOME
REACT_198996
Elastic fibre formation pathway
REACT_198998
Molecules associated with elastic fibres pathway
REACT_206066
Extracellular matrix organization pathway
KEGG
mmu04350
TGF-beta signaling pathway pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_150331
Molecules associated with elastic fibres pathway
REACT_150366
Elastic fibre formation pathway
REACT_118779
Extracellular matrix organization pathway
KEGG
hsa04350
TGF-beta signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.269747
RefSeq NM_019919 NM_206958 XM_006524348 XM_006524350 XM_006524351 XM_006524353 XM_006524354 XM_006524355
OMIM
CCDS CCDS28973 CCDS37694
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca