InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Crim1

Summary

InnateDB Protein

IDBP-255903.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Crim1

Protein Name

cysteine rich transmembrane BMP regulator 1 (chordin like)

Synonyms

AU015004;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000108117

InnateDB Gene

IDBG-198551 (Crim1)

Protein Structure

UniProt Annotation

Function

May play a role in CNS development by interacting with growth factors implicated in motor neuron differentiation and survival. May play a role in capillary formation and maintenance during angiogenesis. Modulates BMP activity by affecting its processing and delivery to the cell surface (By similarity). {ECO:0000250}.

Subcellular Localization

Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed during embryonic development in brain, kidney, spinal chord, testis, lens, vibrissae, pinna, tooth primordia and in specific regions of the CNS. Expressed in adult lens. Displays male-specific expression in the fetal gonads with the strongest expression in the Sertoli cells of developing testis. {ECO:0000269PubMed:10642437, ECO:0000269PubMed:10842084, ECO:0000269PubMed:11084657}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004857	enzyme inhibitor activity
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005515	protein binding
GO:0005520	insulin-like growth factor binding
GO:0030165	PDZ domain binding

Biological Process

GO:0001558	regulation of cell growth
GO:0010951	negative regulation of endopeptidase activity

Cellular Component

GO:0005576	extracellular region
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1354756

InterPro

IPR000867 Insulin-like growth factor-binding protein, IGFBP
IPR001007 von Willebrand factor, type C
IPR004094 Antistasin-like domain
IPR006552 VWC out
IPR011061 Hirudin/antistatin

PFAM

PF00219
PF00093
PF02822

PRINTS

PIRSF

SMART

SM00121
SM00214
SM00215

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9JLL0