InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: STEAP1

Summary

InnateDB Protein

IDBP-25616.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STEAP1

Protein Name

six transmembrane epithelial antigen of the prostate 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000297205

InnateDB Gene

IDBG-25614 (STEAP1)

Protein Structure

UniProt Annotation

Function

Metalloreductase that has the ability to reduce both Fe(3+) to Fe(2+) and Cu(2+) to Cu(1+). Uses NAD(+) as acceptor (By similarity). {ECO:0000250}.

Subcellular Localization

Endosome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Ubiquitously expressed. Highly expressed in prostate tumors. {ECO:0000269PubMed:16609065}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0015267	channel activity
GO:0016491	oxidoreductase activity
GO:0046872	metal ion binding

Biological Process

GO:0006811	ion transport
GO:0055072	iron ion homeostasis
GO:0055085	transmembrane transport
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005911	cell-cell junction
GO:0010008	endosome membrane
GO:0016020	membrane

Protein Structure and Domains

PDB ID

InterPro

IPR013130 Ferric reductase transmembrane component-like domain

PFAM

PF01794

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9UHE8

PhosphoSite

PhosphoSite-Q9UHE8

TrEMBL

UniProt Splice Variant

Entrez Gene

26872

UniGene

RefSeq

NP_036581

HUGO

HGNC:11378

OMIM

604415

CCDS

CCDS5614

HPRD

05106

IMGT

EMBL

AC004969 AC005053 AF186249 BC011802 CH236949

GenPept

AAD15620 AAF17479 AAH11802 EAL24167