Version 5.4
Mus musculus Protein: G6pc2
Summary
InnateDB Protein IDBP-256273.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol G6pc2
Protein Name glucose-6-phosphatase, catalytic, 2
Synonyms G6pc-rs; IGRP;
Species Mus musculus
Ensembl Protein ENSMUSP00000107936
InnateDB Gene IDBG-176067 (G6pc2)
Protein Structure
UniProt Annotation
Function May hydrolyze glucose-6-phosphate to glucose in the endoplasmic reticulum. May be responsible for glucose production through glycogenolysis and gluconeogenesis (By similarity). {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity Specifically expressed in pancreatic islet cells, in particular those of beta-cell origin. Not detected in testis, kidney, muscle, liver, lung, spleen, brain, pituitary, gastric fundus or heart. {ECO:0000269PubMed:10078553, ECO:0000269PubMed:12878201, ECO:0000269PubMed:14722102}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0006094 gluconeogenesis
GO:0042593 glucose homeostasis
GO:0050796 regulation of insulin secretion
Cellular Component
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1277193
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9Z186
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 14378
UniGene Mm.140768
RefSeq NP_001276786
MGI ID
MGI Symbol G6pc2
OMIM
CCDS CCDS71066
HPRD
IMGT
EMBL AF118762 AF118763 AF118764 AF118765 AF118766 AK148465 AL929170 BC111905 Z47787
GenPept AAD28562 AAI11906 BAE28569 CAA87708 CAM24718 CAM24719

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca