InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ppm1b

Summary

InnateDB Protein

IDBP-256293.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ppm1b

Protein Name

protein phosphatase 1B, magnesium dependent, beta isoform

Synonyms

PP2CB;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000107926

InnateDB Gene

IDBG-200886 (Ppm1b)

Protein Structure

UniProt Annotation

Function

Enzyme with a broad specificity. Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it at 'Ser-172'. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB. {ECO:0000269PubMed:23088624}.

Subcellular Localization

Cytoplasm, cytosol. Membrane. Note=Weakly associates at the membrane and N-myristoylation mediates the membrane localization.

Disease Associations

Tissue Specificity

Beta-1 is expressed ubiquitously; beta-2 is expressed exclusively in brain and heart; beta-4 is expressed exclusively in brain and intestine; beta-3 and beta-5 are expressed exclusively in testis and intestine.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0003824	catalytic activity
GO:0004721	phosphoprotein phosphatase activity
GO:0004722	protein serine/threonine phosphatase activity
GO:0030145	manganese ion binding

Biological Process

GO:0006470	protein dephosphorylation
GO:0006499	N-terminal protein myristoylation
GO:0032688	negative regulation of interferon-beta production
GO:0042347	negative regulation of NF-kappaB import into nucleus
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0050687	negative regulation of defense response to virus