InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Ppm1b

Summary

InnateDB Gene

IDBG-200886.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ppm1b

Gene Name

protein phosphatase 1B, magnesium dependent, beta isoform

Synonyms

PP2CB

Species

Mus musculus

Ensembl Gene

ENSMUSG00000061130

Encoded Proteins

IDBP-200888

protein phosphatase 1B, magnesium dependent, beta isoform

IDBP-256293

protein phosphatase 1B, magnesium dependent, beta isoform

IDBP-256297

protein phosphatase 1B, magnesium dependent, beta isoform

IDBP-256299

protein phosphatase 1B, magnesium dependent, beta isoform

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000138032:
The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:84956741-85023991

Strand

Forward strand

Band

Transcripts

ENSMUST00000080217	ENSMUSP00000079107
ENSMUST00000112307	ENSMUSP00000107926
ENSMUST00000112305	ENSMUSP00000107924
ENSMUST00000112304	ENSMUSP00000107923

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 31 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	31 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000287	magnesium ion binding
GO:0003824	catalytic activity
GO:0004721	phosphoprotein phosphatase activity
GO:0004722	protein serine/threonine phosphatase activity
GO:0005515	protein binding
GO:0030145	manganese ion binding

Biological Process

GO:0006470	protein dephosphorylation
GO:0006499	N-terminal protein myristoylation
GO:0032688	negative regulation of interferon-beta production
GO:0035970	peptidyl-threonine dephosphorylation
GO:0042347	negative regulation of NF-kappaB import into nucleus
GO:0043124	negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0050687	negative regulation of defense response to virus