InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dao

Summary

InnateDB Protein

IDBP-256313.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dao

Protein Name

D-amino acid oxidase

Synonyms

AI987963; DAAO; DAMOX; Dao-1; Dao1;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000107911

InnateDB Gene

IDBG-192025 (Dao)

Protein Structure

UniProt Annotation

Function

Regulates the level of the neuromodulator D-serine in the brain. Has high activity towards D-DOPA and contributes to dopamine synthesis. Could act as a detoxifying agent which removes D-amino acids accumulated during aging. Acts on a variety of D- amino acids with a preference for those having small hydrophobic side chains followed by those bearing polar, aromatic, and basic groups. Does not act on acidic amino acids.

Subcellular Localization

Peroxisome.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003884	D-amino-acid oxidase activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0046983	protein dimerization activity
GO:0048037	cofactor binding
GO:0071949	FAD binding

Biological Process

GO:0006551	leucine metabolic process
GO:0006562	proline catabolic process
GO:0036088	D-serine catabolic process
GO:0042416	dopamine biosynthetic process
GO:0055114	oxidation-reduction process
GO:0055130	D-alanine catabolic process
GO:0070178	D-serine metabolic process