Version 5.4
Mus musculus Gene: Dao
Summary
InnateDB Gene IDBG-192025.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dao
Gene Name D-amino acid oxidase
Synonyms AI987963; DAAO; DAMOX; Dao-1; Dao1
Species Mus musculus
Ensembl Gene ENSMUSG00000042096
Encoded Proteins
IDBP-192027
D-amino acid oxidase
IDBP-256313
D-amino acid oxidase
IDBP-535504
D-amino acid oxidase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000110887:
This gene encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological function is not known; it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA receptor. This gene may play a role in the pathophysiology of schizophrenia. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:114003703-114025449
Strand Forward strand
Band F
Transcripts
ENSMUST00000086599 ENSMUSP00000083792
ENSMUST00000112292 ENSMUSP00000107911
ENSMUST00000161610 ENSMUSP00000125588
ENSMUST00000162214
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003884 D-amino-acid oxidase activity
GO:0005102 receptor binding
GO:0005515 protein binding
GO:0016491 oxidoreductase activity
GO:0016641 oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
GO:0046983 protein dimerization activity
GO:0048037 cofactor binding
GO:0071949 FAD binding
Biological Process
GO:0006551 leucine metabolic process
GO:0006562 proline catabolic process
GO:0036088 D-serine catabolic process
GO:0042416 dopamine biosynthetic process
GO:0055114 oxidation-reduction process
GO:0055130 D-alanine catabolic process
GO:0070178 D-serine metabolic process
Cellular Component
GO:0005741 mitochondrial outer membrane
GO:0005777 peroxisome
GO:0005778 peroxisomal membrane
GO:0005829 cytosol
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000110887
View Gene Order
ENSBTAG00000018831
Not yet available
Pathways
NETPATH
REACTOME
REACT_188937
Metabolism pathway
REACT_232845
Metabolism of amino acids and derivatives pathway
REACT_261828
Glyoxylate metabolism pathway
KEGG
mmu00260
Glycine, serine and threonine metabolism pathway
mmu00330
Arginine and proline metabolism pathway
mmu00472
D-Arginine and D-ornithine metabolism pathway
mmu04146
Peroxisome pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_16925
Glyoxylate metabolism pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
KEGG
hsa00330
Arginine and proline metabolism pathway
hsa00472
D-Arginine and D-ornithine metabolism pathway
hsa00260
Glycine, serine and threonine metabolism pathway
hsa04146
Peroxisome pathway
INOH
INOH website
Glycine Serine metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.20115
RefSeq NM_001286396 NM_001286397 NM_010018 XM_006530161 XM_006530162
OMIM
CCDS CCDS19557 CCDS71641
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca