InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Cacna1d

Summary

InnateDB Protein

IDBP-256403.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Cacna1d

Protein Name

calcium channel, voltage-dependent, L type, alpha 1D subunit

Synonyms

8430418G19Rik; C79217; Cacnl1a2; Cchl1a; Cchl1a2; D-LTCC;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000107869

InnateDB Gene

IDBG-142439 (Cacna1d)

Protein Structure

UniProt Annotation

Function

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1D gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin- GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). {ECO:0000269PubMed:16354915}.

Subcellular Localization

Membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Expressed in the inner hair cells (IHC) of the cochlea. {ECO:0000269PubMed:16354915}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005245	voltage-gated calcium channel activity
GO:0005515	protein binding
GO:0008331	high voltage-gated calcium channel activity
GO:0030506	ankyrin binding
GO:0046872	metal ion binding
GO:0051393	alpha-actinin binding
GO:0086059	voltage-gated calcium channel activity involved SA node cell action potential

Biological Process

GO:0006811	ion transport
GO:0006816	calcium ion transport
GO:0007188	adenylate cyclase-modulating G-protein coupled receptor signaling pathway
GO:0007605	sensory perception of sound
GO:0051928	positive regulation of calcium ion transport
GO:0055085	transmembrane transport
GO:0060372	regulation of atrial cardiac muscle cell membrane repolarization
GO:0070509	calcium ion import
GO:0070588	calcium ion transmembrane transport
GO:0086046	membrane depolarization involved in regulation of SA node cell action potential
GO:0086052	membrane repolarization during SA node cell action potential
GO:0086091	regulation of heart rate by cardiac conduction
GO:1901016	regulation of potassium ion transmembrane transporter activity
GO:1901379	regulation of potassium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005891	voltage-gated calcium channel complex
GO:0016020	membrane
GO:0030018	Z disc

Protein Structure and Domains

PDB ID

MGI:88293

InterPro

IPR002077 Voltage-dependent calcium channel, alpha-1 subunit
IPR005446 Voltage-dependent calcium channel, L-type, alpha-1 subunit
IPR005452 Voltage-dependent calcium channel, L-type, alpha-1D subunit
IPR005821 Ion transport domain
IPR013122 Polycystin cation channel, PKD1/PKD2
IPR014873 Voltage-dependent calcium channel, alpha-1 subunit, IQ domain

PFAM

PF00520
PF08016
PF08763

PRINTS

PR00167
PR01630
PR01636

PIRSF

SMART

SM01062

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt