InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Trpv4

Summary

InnateDB Protein

IDBP-256449.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Trpv4

Protein Name

transient receptor potential cation channel, subfamily V, member 4

Synonyms

0610033B08Rik; OTRPC4; Trp12; VR-OAC; VRL-2; VROAC;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000107844

InnateDB Gene

IDBG-192689 (Trpv4)

Protein Structure

UniProt Annotation

Function

Non-selective calcium permeant cation channel probably involved in osmotic sensitivity and mechanosensitivity. Activation by exposure to hypotonicity within the physiological range exhibits an outward rectification. Also activated by low pH, citrate and phorbol esters. Increase of intracellular Ca(2+) potentiates currents. Channel activity seems to be regulated by a calmodulin-dependent mechanism with a negative feedback mechanism. Acts as a regulator of intracellular Ca(2+) in synoviocytes. Plays an obligatory role as a molecular component in the nonselective cation channel activation induced by 4-alpha-phorbol 12,13- didecanoate and hypotonic stimulation in synoviocytes and also regulates production of IL-8 (By similarity). Promotes cell-cell junction formation in skin keratinocytes and plays an important role in the formation and/or maintenance of functional intercellular barriers. {ECO:0000250, ECO:0000269PubMed:11094154, ECO:0000269PubMed:18174177, ECO:0000269PubMed:20413591}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein. Cell junction, adherens junction.

Disease Associations

Tissue Specificity

Detected in liver, kidney, heart, brain cortex, cerebellum and brainstem (at protein level). Expressed in heart, lung, spleen, liver, kidney, brain, skeletal muscle and testis. In the central nervous system, expressed in the lamina terminalis (arched vascular organ and neurons of the subfornical organ), median preoptic area, ventral hippocampal commissure, and ependymal cells of the choroid plexus. In the cochlea, expressed in both inner and outer hair cells, and in marginal cells of the cochlear stria vascularis. Expressed in large neurons of the trigeminal ganglion. In the kidney cortex, strongly expressed by epithelial cells of tubules and much weaker in glomeruli. {ECO:0000269PubMed:11025659, ECO:0000269PubMed:11081638, ECO:0000269PubMed:11094154, ECO:0000269PubMed:12692122, ECO:0000269PubMed:16627472}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005034	osmosensor activity
GO:0005080	protein kinase C binding
GO:0005216	ion channel activity
GO:0005261	cation channel activity
GO:0005262	calcium channel activity
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005524	ATP binding
GO:0008017	microtubule binding
GO:0019901	protein kinase binding
GO:0042169	SH2 domain binding
GO:0043014	alpha-tubulin binding
GO:0048487	beta-tubulin binding
GO:0051015	actin filament binding

Biological Process

GO:0006811	ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0006970	response to osmotic stress
GO:0007015	actin filament organization
GO:0007043	cell-cell junction assembly
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007231	osmosensory signaling pathway
GO:0010977	negative regulation of neuron projection development
GO:0030103	vasopressin secretion
GO:0031117	positive regulation of microtubule depolymerization
GO:0031532	actin cytoskeleton reorganization
GO:0034605	cellular response to heat
GO:0042538	hyperosmotic salinity response
GO:0043622	cortical microtubule organization
GO:0046785	microtubule polymerization
GO:0047484	regulation of response to osmotic stress
GO:0055085	transmembrane transport
GO:0070509	calcium ion import
GO:0071470	cellular response to osmotic stress
GO:0071476	cellular hypotonic response

Cellular Component

GO:0005881	cytoplasmic microtubule
GO:0005886	plasma membrane
GO:0005912	adherens junction
GO:0005925	focal adhesion
GO:0005929	cilium
GO:0009986	cell surface
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030027	lamellipodium
GO:0030175	filopodium
GO:0030426	growth cone
GO:0030864	cortical actin cytoskeleton
GO:0031410	cytoplasmic vesicle
GO:0032587	ruffle membrane

Protein Structure and Domains

PDB ID

MGI:1926945

InterPro

IPR002110 Ankyrin repeat
IPR004729 Transient receptor potential channel
IPR005821 Ion transport domain
IPR008347 Transient receptor potential channel, vanilloid 1-4
IPR008348 Transient receptor potential channel, vanilloid 4
IPR020683 Ankyrin repeat-containing domain

PFAM

PF00023
PF13606
PF00520
PF11929
PF12796

PRINTS

PR01415
PR01768
PR01769

PIRSF

SMART

SM00248

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt