Version 5.4
Mus musculus Gene: Trpv4
Summary
InnateDB Gene IDBG-192689.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Trpv4
Gene Name transient receptor potential cation channel, subfamily V, member 4
Synonyms 0610033B08Rik; OTRPC4; Trp12; VR-OAC; VRL-2; VROAC
Species Mus musculus
Ensembl Gene ENSMUSG00000014158
Encoded Proteins
IDBP-192691
transient receptor potential cation channel, subfamily V, member 4
IDBP-256449
transient receptor potential cation channel, subfamily V, member 4
IDBP-256451
transient receptor potential cation channel, subfamily V, member 4
IDBP-256453
transient receptor potential cation channel, subfamily V, member 4
IDBP-256455
transient receptor potential cation channel, subfamily V, member 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000111199:
This gene encodes a member of the OSM9-like transient receptor potential channel (OTRPC) subfamily in the transient receptor potential (TRP) superfamily of ion channels. The encoded protein is a Ca2+-permeable, nonselective cation channel that is thought to be involved in the regulation of systemic osmotic pressure. Mutations in this gene are the cause of spondylometaphyseal and metatropic dysplasia and hereditary motor and sensory neuropathy type IIC. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:114622152-114658421
Strand Reverse strand
Band F
Transcripts
ENSMUST00000071968 ENSMUSP00000071859
ENSMUST00000112225 ENSMUSP00000107844
ENSMUST00000112222 ENSMUSP00000107840
ENSMUST00000112219 ENSMUSP00000107838
ENSMUST00000112217 ENSMUSP00000107836
ENSMUST00000133019
ENSMUST00000141828
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005034 osmosensor activity
GO:0005080 protein kinase C binding
GO:0005216 ion channel activity
GO:0005261 cation channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005524 ATP binding
GO:0008017 microtubule binding
GO:0019901 protein kinase binding
GO:0042169 SH2 domain binding
GO:0043014 alpha-tubulin binding
GO:0048487 beta-tubulin binding
GO:0051015 actin filament binding
Biological Process
GO:0006811 ion transport
GO:0006874 cellular calcium ion homeostasis
GO:0006970 response to osmotic stress
GO:0006971 hypotonic response
GO:0007015 actin filament organization
GO:0007043 cell-cell junction assembly
GO:0007204 positive regulation of cytosolic calcium ion concentration
GO:0007231 osmosensory signaling pathway
GO:0010977 negative regulation of neuron projection development
GO:0030103 vasopressin secretion
GO:0031117 positive regulation of microtubule depolymerization
GO:0031532 actin cytoskeleton reorganization
GO:0034605 cellular response to heat
GO:0042538 hyperosmotic salinity response
GO:0043622 cortical microtubule organization
GO:0046785 microtubule polymerization
GO:0047484 regulation of response to osmotic stress
GO:0055085 transmembrane transport
GO:0070509 calcium ion import
GO:0070588 calcium ion transmembrane transport
GO:0071470 cellular response to osmotic stress
GO:0071476 cellular hypotonic response
Cellular Component
GO:0005881 cytoplasmic microtubule
GO:0005886 plasma membrane
GO:0005912 adherens junction
GO:0005925 focal adhesion
GO:0005929 cilium
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030027 lamellipodium
GO:0030175 filopodium
GO:0030426 growth cone
GO:0030864 cortical actin cytoskeleton
GO:0031410 cytoplasmic vesicle
GO:0032587 ruffle membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000111199
View Gene Order
ENSBTAG00000000031
Not yet available
Pathways
NETPATH
REACTOME
REACT_196640
Stimuli-sensing channels pathway
REACT_262350
Ion channel transport pathway
REACT_253400
Transmembrane transport of small molecules pathway
REACT_227861
TRP channels pathway
KEGG
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_160189
Stimuli-sensing channels pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_25300
Ion channel transport pathway
REACT_169333
TRP channels pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E9Q7L7 Q3TYG5 V9SH16
UniProt Splice Variant
Entrez Gene 63873
UniGene Mm.266450
RefSeq NM_022017 XM_006530432 XM_006530433
OMIM
CCDS CCDS19568
HPRD
IMGT
MGI ID MGI:1926945
MGI Symbol Trpv4
EMBL AC124228 AK158652 KF752548
GenPept AHC55219 BAE34598
RNA Seq Atlas 63873

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca