Version 5.4
Mus musculus Protein: Trpv4
Summary
InnateDB Protein IDBP-256451.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol Trpv4
Protein Name transient receptor potential cation channel, subfamily V, member 4
Synonyms 0610033B08Rik; OTRPC4; Trp12; VR-OAC; VRL-2; VROAC;
Species Mus musculus
Ensembl Protein ENSMUSP00000107840
InnateDB Gene IDBG-192689 (Trpv4)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005034 osmosensor activity
GO:0005216 ion channel activity
GO:0005262 calcium channel activity
GO:0005515 protein binding
Biological Process
GO:0006811 ion transport
GO:0006970 response to osmotic stress
GO:0007231 osmosensory signaling pathway
GO:0030103 vasopressin secretion
GO:0042538 hyperosmotic salinity response
GO:0047484 regulation of response to osmotic stress
GO:0055085 transmembrane transport
GO:0070588 calcium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0005929 cilium
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1926945
InterPro IPR002110 Ankyrin repeat
IPR005821 Ion transport domain
IPR008347 Transient receptor potential channel, vanilloid 1-4
IPR008348 Transient receptor potential channel, vanilloid 4
IPR020683 Ankyrin repeat-containing domain
PFAM PF00023
PF13606
PF00520
PF11929
PF12796
PRINTS PR01415
PR01768
PR01769
PIRSF
SMART SM00248
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL V9SH16
UniProt Splice Variant
Entrez Gene 63873
UniGene Mm.266450
RefSeq
MGI ID
MGI Symbol Trpv4
OMIM
CCDS
HPRD
IMGT
EMBL AC124228 AK158652 KF752548
GenPept AHC55219 BAE34598

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca