InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Prkcd

Summary

InnateDB Protein

IDBP-256481.5

Last Modified

2012-02-14 [Report errors or provide feedback]

Gene Symbol

Prkcd

Protein Name

protein kinase C, delta

Synonyms

AI385711; D14Ertd420e; PKC[d]; Pkcd; PKCdelta;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000107821

InnateDB Gene

IDBG-142854 (Prkcd)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 69 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	69 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0046872	metal ion binding

Biological Process

GO:0006468	protein phosphorylation
GO:0016064	immunoglobulin mediated immune response
GO:0032613	interleukin-10 production
GO:0032615	interleukin-12 production
GO:0035556	intracellular signal transduction
GO:0042100	B cell proliferation
GO:0045087	innate immune response (InnateDB)
GO:2001235	positive regulation of apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005911	cell-cell junction
GO:0016363	nuclear matrix

Protein Structure and Domains

PDB ID

MGI:97598

InterPro

IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol binding
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020454 Diacylglycerol/phorbol-ester binding
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF07714
PF00130

PRINTS

PR00109
PR00008

PIRSF

SMART

SM00109
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

PhosphoSite

PhosphoSite-

TrEMBL

Q1MX40

UniProt Splice Variant

Entrez Gene

18753

UniGene

Mm.487003

RefSeq

MGI ID

MGI Symbol

Prkcd

OMIM

CCDS

HPRD

IMGT

EMBL

AB201456 AC154646

GenPept

BAE93685